When Christopher Columbus set out to find the western passage to India via the Atlantic, he had no idea where the goal line was. In fact many doubted the goal line could even be reached by sailing west.
As I think about the uncertainty of our efforts to control diabetes and to help find a cure, I sometimes feel a bit like Columbus in the middle of the ocean. There are no guarantees; there's no one to reassure you that you're on the right course and there's no clear idea how long the journey will take.
Hope is sometimes the only thing you have to keep you afloat.