When we think of insulin and glucose regulation, the two organs that come to mind are the pancreas and liver. Research by Columbia researcher, Dr. Gerard Karsenty found that the bones also play a vital role - especially in type 2 diabetes.
Last summer Karsteny published a study that in mice prone to Type 2 diabetes, an increase in osteocalcin addressed the twin problems of insulin resistance and low insulin production. That is, it made the mice more sensitive to insulin and it increased their insulin production, thus bringing their blood sugar down. As a bonus, it also made obese mice less fat.
If osteocalcin works similarly in humans, it may prove to be a novel treatment for type 2 patients and augment the regimen for type 1 diabetics.